36q. which enzyme is inhibited by aminophylline ?
a. monoamine oxidase
b. alcohol dehydrogenase
c. phosphodiesterase
d. cytochrome P-450
answer: c . phosphodiesterase .
37q. milk-alkali syndrome may be caused by ingestion of ?
a. calcium carbonate
b. magnesium sulphate
c. aluminium trisilicate
d. aluminium hydroxide
answer: a . calcium carbonate .
38q. drugs used in obesity are ?
a. sibutramine
b. orlistat
c. insulin
d. mephenteramine
e. thyroxine
answer: a and b . sibutramine and orlistat .
39q. which of the following statements are true about isotretinoin ?
a. it is a vitamin A analogue
b. it is used in cystic acne
c. safe in pregnancy
d. used in psoriasis
e. bony hyperostosis is a side effect
answer: a , c , e . its use is unsafe in pregnancy and it is not used in psoriasis .
40q. OCP produces which of the following in the liver ?
a. cholangiosarcoma
b. adenoma
c. cirrhosis
d. atropic changes
answer: b . adenoma . hepatic adenoma is one of the side effects of long standing OCP .
41q. a drug is more likely to cause toxicity in elderly patients due to all of the following reasons except ?
a. decreased renal excretion of the drugs
b. decreased hepatic metabolism
c. increased receptor sensitivity
d. decreased volume of distribution
answer: d . there is actually increased volume of distribution for fat soluble drugs in elderly individuals. this results in decreased elimination of the drug which leads to toxicity .
the other causes which lead to increased chance of drug toxicity in elderly are ( other than mentioned above in the options )
1. decreased lean body mass
2. decreased total body water
check out a similar kind of question below
42q. all are reasons for reducing drug dosage in elderly except ?
a. they are lean and their body mass is less
b. have decreasing renal function with age
c. have increased baroreceptor sensitivity
d. body water is decreased
answer: c. u must be wondering the above question states that receptor sensitivity increases with age and here this question states that it is true . but the statement that receptor sensitivity of the target organs increases with age is true for most of the target organs but not the baroreceptors . infact the sensitivity of the baroreceptors decreases with age . this leads to impaired blood pressure response to standing and volume depletion . therefore dosage should be increased in such situtaions .
43q. find the true statement ?
a. antimalarial drug safe in pregnancy is chloroquine
b. anticoagulation drug safe in pregnancy is heparin
c. antithyroid drug safe in pregnancy is propyl thiouracil
d. muscle relaxant safe in pregnancy is d-tubocurarine
e. all the statements are true
answer: e. all are true statements .
44q. a patient was started on antihypertensive medication and landed up in renal failure . which could be the probable offending drug here ?
a. beta blocker
b. alpha blocker
c. calcium channel blocker
d. ACE inhibitor
e. clonidine
answer: d . ACE inhibitor .
45q. PSVT is best treated by ?
a. adenosine
b. lidocaine
c. phenytoin
d. quinidine
answer: a . adenosine .
46q. which of the following drug is contraindicated in pregnancy ?
a. clonidine
b. enalapril
c. methyl dopa
d. hydralazine
answer: b . enalapril . ACE inhibitors are absolutely contraindicated in pregnancy .
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