Sunday, August 17, 2008

18 - hypolipidemic drugs - mechanism of action

There are mainly four type of hypolipidemic drugs , they are

  1. statins : they act by inhibiting the enzyme HMG CoA reductase which is the rate limiting step of cholesterol synthesis .

examples of statins are : lovastatin, mevastatin, simvastatin , rosuvastatin .

  1. fibric acid derivatives : these drugs act by activating the lipoprotein lipase .

examples are : gemfibrozil , clofibrate .

  1. bile acid resins : these drugs act by interrupting the enterohepatic recycling of bile acids .

examples of bile acid resins are : cholestyramine and cholestipol .

  1. nicotinic acid : this drug acts by unclear mechanisms but it is believed that it acts by inhibition of lipolysis .

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