Sunday, September 20, 2009

53 - Benzodiazepine interactions with other drugs

Benzodiazepine interactions with other drugs.

Drug
Effects
Antacids
Decreased absorption of benzodiazepines
Cimetidine
Increased half-life of diazepam and 
triazolam
Contraceptives
Increased levels of diazepam and 
triazolam
Digoxin
Alprazolam and diazepam raise 
digoxin level
Disulfiram
Increased duration of action of sedatives
Isoniazid
Increased plasma diazepam
Levodopa
Inhibition of antiparkinsonism effect
Propoxyphene
Impaired clearance of diazepam
Rifampin
Decreased plasma diazepam
Warfarin
Decreased prothrombin time

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