8 - pharmacology mcqs - 13 to 24

13) Drug induced parkinsonism is treated by

a. Carbidopa

b. Bromocriptine

c. Benzhexol

d. Selegiline

Answer : C) Benzhexol

Reference: KDTripathi 5^th Edition Page 388

14) Drug with high degree of Photosensitivity is

a. Tetracycline

b. Doxycycline

c. Minocycline

d. Methacycline

Answer : b) Doxycline

Reference: KDTripathi 5^th Edition Page 672

15) Minoxidil

a. Topical Application is used in Alopecia

b. Acts on Arteriolar smooth muscles causing relaxation

c. Leads to Sodium Retention

d. All of the above

Answer : D) All of the above

Reference: KDTripathi 5^th Edition Page 513

16) Thrombolytic therapy with Streptokinase is Contraindicated in all of the following except

a. Supra ventricular Tachycardia

b. Recent Trauma

c. Recent Cerebral Bleeding

d. Recent Surgery

Answer : a) Supra ventricular Tachycardia

Reference: KDTripathi 5^th Edition Page 571

17) Carbenazolone Sodium

a. Promotes Ulcer Healing

b. Slows down Prostaglandin degradation

c. Derived from Glycyrrhetinic Acid

d. All of the above

Answer : d) All of the above

Reference: KDTripathi 5^th Edition Page 597

18) Treatment of Lepra Reaction includes

a. Thalidomide

b. Steroids

c. Clofazamine

d. All of the above

Answer : D) All of the above

Reference: KDTripathi 5^th Edition Page 714

19) Drug used for treatment of Methicillin Resistant Staphylococcus Aureus

a. Teicoplanin

b. Vancomycin

c. Both

d. None

Answer : C) Both

Reference: KDTripathi 5^th Edition Page 691

20) Which is obtained from a natural source Naturallly acquiring product –

a. Physostigmine

b. Pilocarpine

c. Heparin

d. All of the above

Answer : D) All of the above

Reference: KDTripathi 5^th Edition Page 81, 561

Physostigmine occurs naturally in Calabar or Ordeal bean, Ripe seed of Physostigm venenosum, Heparin in Liver and granulocytes of mast cells, Sulfonamides in Azo dyes, Liq.paraffin in Hydrocarbons.

21) Mechanism of action of Aspirin is inhibition of

a. Thromboxane A2 Synthesis

b. Phosphodiesterase

c. HMG- CoA Reductase

d. Pancreatic Lipase

Answer : A) Thromboxane A2 Synthesis

Reference: Harper 27^th Edition Page 204

22) Folic acid

a. Is also called as Pteroyl Glutamic Acid

b. Is useful in Carriage of one Carbon atom moiety

c. Tetra hydro folate is the active form

d. All of the above

Answer : d) All of the above

Reference: Chaterjee 6^th Edition Page 174

23) Gene therapy is used for all the following except

a. Gene Addition

b. Gene Correction

c. Modify Vascular Biology

d. None

Answer : d) None

Reference: Harrison 16^th Edition Page 392

24) Local Anaesthetics act by

a. Blocking Na and Preventing depolarisation

b. Inhibiting Aldose reductase

c. Increasing degradation of Adrenaline

d. None of the above

Answer : a) Blocking Na and Preventing depolarisation

Reference: KDTripathi 5^th Edition Page 321

7 - pharmacology mcqs - 1 to 12

1) Actions of opiates in man are all except

a. Constipation

b. Mydriasios

c. Vomiting

d. Analgesia

Answer : b) Mydriasis

Reference: Tripathi 5^th Edition Page 421

2) Drug of choice for Prophylaxis of meningococcal meningitis is

a. Rifampicin

b. Penicillin

c. Erythromycin

d. Septran

Answer : a) Rifampicin

Reference: Tripathi 5^th Edition Page 701

3) Gray Baby syndrome is caused by

a. Chloramphenicol

b. Cycloserin

c. Kanamycin

d. Thioacetazone

Answer : a) Chloramphenicol

Reference: Tripathi 5^th Edition Page 675

4) Which of the following is a Cholestatic drug

a. Erythromycin

b. Phenothiazines

c. Oral Contraceptives

d. All of the above

Answer : d) All of the above

Reference: Harrison 15^th Edition Page 434

5) Ceftriaxone is

a. II Generation short acting

b. III generation long acting

c. active against beta lactamase

d. IV generation used orally

Answer : b) III Generation Long Acting

Reference: Tripathi 5^th Edition Page 665

6) Treatment of bacterial vaginosis. Drug of choice is

a. Ampicillin

b. Metronidazole

c. Ciprofloxacin

d. Fluconazole

Answer : Metronidazole

Reference: Dutta Gynaec 2^nd Edition Page 151

7) Bioavailability is defined as

a. The percentage of drug that is detected in the systemic circulation after its administration

b. The volume of plasma completely cleared of a specific compound per unit time and measured as a test of kidney function.

c. Both

d. None

Answer : The percentage of drug that is detected in the systemic circulation after its administration

Reference: Tripathi 5^th Edition Page 15

8) Which of the following is a Prodrug

a. Enalapril

b. Dopamine

c. AMpicillin

d. Prednisolone

Answer d) Enalapril:

Reference: Tripathi 5^th Edition Page 20

9) Cyclosporine side effect all except

a. Post-transplant lymphoproliferative disorders (PTLDs),

b. nephrotoxicity

c. tremors

d. Hypotension

Answer : d) Hypotension

Reference: Tripathi 5^th Edition Page 788

10) True about Sumatriptan

a. Antagonist of Serotonin

b. Interacts with alpha and beta adrenergic receptors

c. Has antimigranic activity

d. Can be used in a patient with Ischemic Heart disease

Answer : Has antimigranic activity

Reference: Tripathi 5^th Edition Page 153

11) Anticholine esterase with effect on CNS

a. Physostigmine

b. Neostigmine

c. Dacrine

d. Edrophonium

Answer :physostigmine ( check )

Reference: Tripathi 5^th Edition Page

12) DOC for Herpes

a. Acyclovir

b. Zidovudine

c. Indinavir

d. Ribavarin

Answer : a) Acyclovir

Reference: Tripathi 5^th Edition Page 726

6 - inhaled corticosteroids mcqs

Question 1
Ideal inhaled corticosteroid should have:
High pulmonary residence time
High protein binding after leaving the lungs
High systemic clearance
All the above---------------

Question 2
Which statement is not true with regard to corticosteroid receptors?
They are intracellular
Same receptor mediates both beneficial and adverse effects of coticosteroid
There are no coticosteroid receptors in the eye lens
None of the above-----------------

Question 3
The latest addition to the list of inhaled corticosteroid is:
Ciclesonide-------------
Budesonide
Beclomethasone dipropionate
Fluticasone propionate

Question 4
Which of the following formulations gives the highest drug deposition in the lungs?
Powder
Suspension
Solution----------
Is equal with all of the above

Question 5
Of the following, which drug has highest receptor affinity?
Fluticasone propionate--------------
Dexamethasone
Beclomethasone dipropionate
Desisobutyryl – ciclesonide

Question 6
Which of the following corticosteroids is inhaled in pharmacologically inactive form?
Beclomethasone dipropionate------------
Fluticasone propionate
Dexamethasone
None of the above

Question 7
Which of these statements is false? In approved dosages inhaled corticosteroids:
Inhibit proliferation of inflammatory cells
Do not suppress endogenous cortisol release
Do not cause osteoporosis
None of the above-------------

Question 8
Which of these statements is true? In approved dosages inhaled corticosteroids cause:
Weight gain
Glaucoma
Cataract
None of the above------------

Question 9
Which of these is a side effect of oral but not of inhaled corticosteroids when given in recommended dosage?
Moon face
Increased risk of fracture
Disturbed carbohydrate metabolism
All of the above-------------

Question 10
Which of the following statements is not true with regard to use of inhaled corticosteroid ?
It should be used as first line therapy in asthma
It should be used as first line therapy in chronic obstructive pulmonary disease-------------
It should not be used in children
None of the above

Question 11
Inhaled corticosteroids are used as first line therapy in:
Mild persistent asthma
Moderate persistent asthma
Severe persistent asthma
All the above--------------

Question 12
Which of these statements is true with regard to growth in children with asthma?
Uncontrolled asthma can affect growth
Inhaled corticosteroid with low oral bioavailibility should be used
Inhaled corticosteroid in recommended dosage do not prevent children from reaching adult height
All the above------------

Question 13
What percentage of ciclesonide is deposited in the lung when delivered via the inhaled route?
10% - 20%
21% - 30%
31% - 40%
>50%-----------------

Question 14
Ciclesonide is the safest inhaled corticosteroid because:
Of low oro-pharyngeal deposition
It has high plasma protein binding
Of rapid clearance
All the above statements are true--------------

Question 15
Recommended dosage of ciclesonide in asthma is:
80 – 640 mcg once daily--------------
640 -800 mcg once daily
800 – 1000 mcg once daily
1000 – 1640 mcg once daily