Friday, September 11, 2009

51 - Antimicrobial chemotherapy - Rest of drugs

Inhibitors of nucleic acid synthesisQuinolonesDNA gyraseBactericidal
NovobiocinDNA gyraseBacteriostatic
FlucytosineFungal thymidylate synthetaseFungicidal
RifampinDNA-dependent RNA polymeraseBactericidal


Inhibitors of folate metabolismSulfonamidesPteroic acid synthetaseBacteriostatic
TrimethoprimDihydrofolate reductaseBacteriostatic


Inhibitor of mycolic acid synthesisIsoniazidMycobacterial mycolic acid biosynthesisBactericidal


Alteration of cytoplasmic membranePolymyxinsBacterial membrane permeabilityBactericidal
PolyenesFungal membrane permeabilityFungicidal
AzolesFungal ergosterol biosynthesisFungicidal


50 - Antimicrobial chemotherapy - Protein biosynthesis inhibitors

Streptomycin     30S ribosomal subunitBactericidal
Gentamicin     30S ribosomal subunit               
Bactericidal
Tetracycline     30S ribosomal subunitBacteriostatic
Spectinomycin     30S ribosomal subunitBacteriostatic
Chloramphenicol     50S ribosomal subunitBacteriostatic
Erythromycin     50S ribosomal subunitBacteriostatic
Clindamycin     50S ribosomal subunitBacteriostatic
Griseofulvin     Microtubule functionFungistatic


49 - Antimicrobial chemotherapy - Cell wall synthesis inhibitors

             
 
 AGENT

Cycloserine
     SITE OF ACTION


     Peptidoglycan tetrapeptide side chain
    EFFECT

    Bactericidal

Phosphomycin

     Formation of N-acetylmuramic acid

    Bactericidal

Bacitracin

     Membrane carrier molecule

    Bactericidal

Penicillins

     Peptidoglycan cross-linking

    Bactericidal

Cephalosporins
carbapenems

,     Peptidoglycan cross-linking

    Bactericidal

Vancomycin

     Translocation of cell wall   intermediates

    Bactericidal



48 - Atypical Antipsychotic drugs

Atypical antipsychotics are those drugs which act as antipsychotics but atypically have a very low risk of producing adverse extrapyramidal neurological side effects . These are

1. Risperidone

2. Quetiapine

3. Arisipiprazole

4. Clozapine

5. Olanzapine

6. Ziprasodine

Click here to read the mnemonic used to remember these drugs .

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