37 - pharmacology mcqs - 58 to 68

58q. digoxin is contraindicated in ?

a. SVT

b. AF

c. CHF

d. HOCM

answer: d . HOCM - hypertrophic obstructive cardiomyopathy .

59q. digoxin is not indicated in ?

a. atrial flutter

b. atrial fibrillation

c. high output failure

d. PSVT

answer: c . high output failure .

60q. which of the following drugs is a topoisomerase 1 inhibitor ?

a. doxorubicin

b. irinotecan

c. etoposide

d. vincristine

answer: b . irinotecan . topotecan and irinotecan are campothecin analogues .

61q. the treatment of contacts of meningococcal meningitis ?

a. rifampicin

b. erythromycin

c. pencillin

d. cephalosporins 

answer: a . rifampicin .

62q. SLE like syndrome is most commonly associated with the administration of the following drug ?

a. rifampicin

b. procainamide

c. digitalis

d. phenytoin

answer: b . procainamide .

63q. cyclosporine acts by inhibiting the production of ?

a. IL 1

b. IL 2

c. IL 3

d. macrophages

answer: b . IL 2 .

64q. drugs avoided in G6PD deficiency ?

a. chloramphenicol

b. quinidine

c. nitrofurantoin

d. dapsone

e. streptomycin 

answer: a,b,c,d. here is a list of drugs which cause hemolysis in a  G6PD patient . 

65q. volume of  distribution of drugs is altered in ?

a. obesity

b. athletes

c. pregnancy

d. older age 

e. neonate

answer: a,c,d,e. all except athletes .

66q. the drug of choice to treat severe hypertension due to acute nephritis in children is ?

a. propranolol

b. reserpine

c. frusemide

d. nifedipine

answer: d . nifedipine .

67q. digoxin is eliminated from the body by ?

a. tubular filtration

b. hepatic conjugation

c. glomerular filtration

d. oxidation

answer: c . glomerular filtration .

68q. drug of choice in prinzmetal's angina ?

answer: diltiazem .

36 - pharmacology mcqs - 47 to 57

47q. drug of choice in drug induced parkinsonism ?

a. levodopa

b. benzhexol

c. amantadine

d. carbidopa 

answer: b . benzhexol .

48q. drug of choice for renal colic ?

a. methadone

b. pentazocine

c. voveran

d. piroxicam

answer: c . voveran . this is nothing but diclofenac sodium .

49q. what is the chemical name of heroin ?

answer: diacetyl morphine .

50q. the drug of choice for attention deficit hyperactivity disorder ?

a. haloperidol

b. imipramine

c. methyl phenidate

d. lecithin 

answer: c . methyl phenidate .

51q. drug of choice for insomnia in elderly ?

a. diazepam

b. fluoxetin

c. flurazepam

d. oxazepam

answer: d . oxazepam .

52q. aspirin is used in MI because ?

a. decreases thromboxane synthesis

b. has analgesic effect

c. reduces prostaglandin synthesis

d. reduces cardiac work 

answer: a . decreases thromboxane synthesis .

53q. which is the treatment of choice for myoclonic epilepsy in children ?

answer: valproate .

54q. which of the following is not an amide ?

a. lignocaine

b. procaine

c. mepivacaine

d. dibucaine

answer: b . this is the simplest question ever . just remember all the amides will have two " i " s in their names . as simple as that .

55q. long term  use of lithium causes ?

a. peripheral neuropathy

b. hypothyroidism

c. anaemia

d. jaundice

answer: b . hypothyroidism .

56q. carbamazepine is not used in ?

a. mania

b. partial seizure

c. trigeminal neuralgia

d. migraine

answer: d . migraine . remember that carbamazepine is the drug of choice in trigeminal neuralgia.

57q. all are features of ethambutol toxicity except ?

a. retrobulbar neuritis

b. colour vision defects

c. hyperuricemia

d. hypercalcemia

answer: d . hypercalcemia . other antitubercular drugs which cause hyperuricemia are pyrazinamide . 

35 - P450 microsomal enzyme inducers and inhibitors

A.  microsomal enzyme P450 inhibitors :

1. ketoconazole

2. ciprofloxacin

3. allopurinol

4. omeprazole

5. erythromycin

6. cimetidine

B. microsomal enzyme P450 inducers :

1. rifampicin

2. isoniazid

3. glucocorticoids

4. phenobarbitone

5. phenytoin

6. phenylbutazone

7. chloral hydrate

8. griseofulvin

9. DDT

34 - pharmacology mcqs - 36 to 46

36q. which enzyme is inhibited by aminophylline ?

a. monoamine oxidase

b. alcohol dehydrogenase

c. phosphodiesterase 

d. cytochrome P-450

answer: c . phosphodiesterase .

37q. milk-alkali syndrome may be caused by ingestion of ?

a. calcium carbonate

b. magnesium sulphate

c. aluminium trisilicate

d. aluminium hydroxide

answer: a . calcium carbonate .

38q. drugs used in obesity are ?

a. sibutramine

b. orlistat

c. insulin

d. mephenteramine

e. thyroxine

answer: a and b . sibutramine and orlistat .

39q. which of the following statements are true about isotretinoin ?

a. it is a vitamin A analogue

b. it is used in cystic acne

c. safe in pregnancy

d. used in psoriasis

e. bony hyperostosis is a side effect

answer: a , c , e . its use is unsafe in pregnancy and it is not used in psoriasis .

40q. OCP produces which of the following in the liver ?

a. cholangiosarcoma

b. adenoma

c. cirrhosis

d. atropic changes

answer: b . adenoma . hepatic adenoma is one of the side effects of long standing OCP .

41q. a drug is more likely to cause toxicity in elderly patients due to all of the following reasons except ?

a. decreased renal excretion of the drugs

b. decreased hepatic metabolism

c. increased receptor sensitivity

d. decreased volume of distribution 

answer: d . there is actually increased volume of distribution for fat soluble drugs in elderly individuals. this results in decreased elimination of the drug which leads to toxicity .

the other causes which lead to increased chance of drug toxicity in elderly are ( other than mentioned above in the options )

1. decreased lean body mass

2. decreased total body water 

check out a similar kind of question below

42q. all are reasons for reducing drug dosage in elderly except ?

a. they are lean and their body mass is less

b. have decreasing renal function with age

c. have increased baroreceptor sensitivity

d. body water is decreased 

answer: c. u must be wondering the above question states that receptor sensitivity increases with age and here this question states that it is true . but the statement that receptor sensitivity of the target organs increases with age is true for most of the target organs but not the baroreceptors . infact the sensitivity of the baroreceptors decreases with age . this leads to impaired blood pressure response to standing and volume depletion . therefore dosage should be increased in such situtaions . 

43q. find the true statement ?

a. antimalarial drug safe in pregnancy is chloroquine

b. anticoagulation drug safe in pregnancy is heparin

c. antithyroid drug safe in pregnancy is propyl thiouracil

d. muscle relaxant safe in pregnancy is d-tubocurarine 

e. all the statements are true

answer: e. all are true statements .

44q. a patient was started on antihypertensive medication and landed up in renal failure . which could be the probable offending drug here ?

a. beta blocker

b. alpha blocker

c. calcium channel blocker

d. ACE inhibitor

e. clonidine

answer: d . ACE inhibitor .

45q. PSVT is best treated by ?

a. adenosine

b. lidocaine

c. phenytoin

d. quinidine

answer: a . adenosine . 

46q. which of the following drug is contraindicated in pregnancy ?

a. clonidine

b. enalapril

c. methyl dopa

d. hydralazine

answer: b . enalapril . ACE inhibitors are absolutely contraindicated in pregnancy . 

33 - finasteride mcqs

Q: all  the following statements about finasteride are true except ?

a. it is used in the medical treatment of benign prostatic hypertrophy

b. impotence is well documented after its use

c. it blocks the conversion of dihydrotestosterone to testosterone

d. it is a 5 alpha reductase inhibitor

answer: c . it blocks the conversion of testosterone to dihydrotestosterone but not the reverse . 

such a tricky question , i wonder what the examiners think , that we are geniuses or wat ? anyway more info about finasteride here .

 Finasteride (marketed as Proscar, Propecia, Fincar, Finpecia, Finax, Finast, Finara, Finalo, Prosteride, Gefina, Appecia,Finasterid IVAX, Finasterid Alternova) is a synthetic antiandrogen which acts by inhibiting type II 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT). It is used as a treatment in benign prostatic hyperplasia (BPH) in low doses, andprostate cancer in higher doses. A May, 2008 study indicates that Finasteride reduces the rate of prostate cancer by 30% . It is also indicated for use in combination with doxazosin therapy to reduce the risk for symptomatic progression of BPH. Additionally, it is registered in many countries for androgenetic alopecia (male-pattern baldness).

Finasteride was approved initially in 1992 as Proscar, a treatment for prostate enlargement, but the sponsor had studied 1 mg of finasteride and demonstrated hair growth in male pattern hair loss. On December 22, 1997, the U.S. Food and Drug Administrationapproved finasteride to treat male pattern hair loss.