46 - Molecularly targeted anticancer drugs

These drugs target a specific molecule and function as anticancer agents


1. imatinib
2. tretinoin
3. bexarotene
4. gemtuzumab ozogamicin
5. denileukin diftitox
6. gefitinib
7. erlotinib
8. dasatinib
9. sorafenib
10. sunitinib

44 - Antimetabolites drugs ( Anticancer drugs )

These drugs are indirect DNA-interacting agents . examples are :


1. deoxycoformycin (pentostatin) ^

2. 6-mercaptopurine ^

3. 6-thioguanine ^

4. azathioprine ^

5. 2-chlorodeoxy adenosine (cladribine) ^

6. fludarabine phosphate ^

7. asparaginase
8. hydroxy urea
9. capacitabine "

10. cytosine arabinoside "

11. azacytidine "

12. gemcitabine "

13. 5-fluorouracil "

14. methotrexate ~

15. pemetrexed ~
---------------------------------
^ (1-6) Purine analogs and related inhibitors .
" (9-13) Pyramidine analogs
~ (14,15) Folic acid analogs 

43 - Antitumor antibiotics ( Anticancer agents )

These drugs are also direct DNA-interacting agents . examples are :


1. bleomycin
2. actinomycin D
3. mitomycin C
4. etoposide ( VP16-213 )
5. topotecan
6. irinotecan ( CPT II )
7. doxorubicin and daunorubicin
8. idarubicin
9. epirubicin
10. mitoxantrone

42 - Alkylating agents ( Anticancer drugs )

These drugs are direct DNA-interacting agents . examples are :


1. cyclophosphamide*
2. mechlorethamine*
3. chlorambucil*
4. melphalan(L-sarcolysin)*
5. ifosfamide*
 

6. lomustine ( CCNU ) %

7. carmustine ( BCNU ) %

8. streptozocin (streptozotocin) %


9. dacarbazine ( DTIC; dimethyltriazenoimidazole carboxamide ) =

10. temozolomide =


11. oxaliplatin -
12. cisplatin -
13. carboplatin -

14. altretamine ( formerly hexamethyl melamine ) +
15. thiotepa + 

16. procarbazine (N-methyl hydrazine, MIH) !


17. busulfan $
 -----------------------------

* (1-5) Nitrogen mustards 
%  (6-8) Nitrosoureas
=  (9,10) Triazenes
-  (11-13) Platinum coordination complexes
+ (14,15) Ethyleneimines and methylmelamines
! (16) Methylhydrazine derivative
$ (17) Alkyl sulfonate