Sunday, February 21, 2010

61 - Drugs potentially harmful in Porphyria

1. BARBITURATES : The effect of barbiturates on ALA synthetase can cause dangerous disease exacerbations in persons with intermittent porphyria.Because barbiturates enhance porphyrin synthesis, they are absolutely contraindicated in patients with acute intermittent porphyria or porphyria variegata.
2. ETHCHLORVYNOL: Ethchlorvynol may enhance the hepatic metabolism of other drugs such as oral anticoagulants, and it is contraindicated in patients with intermittent porphyria.
3. CHLOROQUINE : It should not be used for malaria in patients with porphyria cutanea tarda but is used in smaller doses for treatment of the underlying disease.


Documented Porphyrinogenic 
Carbamazepine
Carisoprodol
Chloramphenicol
Clindamycin
Dextropropoxyphene
Dihydralazine
Dihydroergotamine
Drospirenone + estrogen
Dydrogesterone
Etonogestrel
Fosphenytoin sodium
Hydralazine
Hydroxyzine
Indinavir
Ketamine
Ketoconazole
Lidocaine
Lynestrenol
Lynestrenol + estrogen
Mecillinam
Medroxyprogesterone
Megestrol
Methylergometrine
Methyldopa
Mifepristone
Nicotinic acid/meclozine/hydroxyzine
Nitrofurantoin
Norethisterone
Norgestimate + estrogen
Orphenadrine
Phenobarbital
Phenytoin
Pivampicillin
Pivmecillinam
Primidone
Rifampicin
Ritonavir
Spironolactone
Sulfadiazine + trimethoprim
Tamoxifen
Testosterone, inj.
Thiopental
Trimethoprim
Valproic acid


Probably Porphyrinogenic 
Altretamine
Lidocaine
Aminophylline
Lopinavir
Amiodarone
Lutropin alfa
Amitriptyline
Lymecycline
Amlodipine
Meclozine
Amprenavir
Medroxyprogesterone + estrogen
Aprepitant
Atorvastatin
Metoclopramide
Azathioprine
Metronidazole
Bosentan
Metyrapone
Bromocriptine
Moxonidine
Buspirone
Nandrolone
Busulfan
Nefazodone
Butylscopolamine
Nelfinavir
Cabergoline
Nevirapine
Ceftriaxone + lidocaine
Nifedipine
Cerivastatin
Nimodipine
Cetirizine
Nitrazepam
Cholinetheophyllinate
Norethisterone
Clarithromycin
Nortriptyline
Clemastine
Oxcarbazepine
Clonidine
Oxytetracycline
Cyclizine
Paclitaxel
Cyproterone
Paroxetine
Danazol
Phenazone + caffeine
Delavirdine
Pioglitazone
Desogestrel + estrogen
Probenecid
Diazepam
Progesterone, vaginal gel
Dienogest + estrogen
Quinidine
Diclofenac
Rabeprazole
Diltiazem
Raloxiphene
Diphenhydramine
Rifabutin
Disopyramide
Riluzole
Disulfiram
Risperidone
Drospirenone + estrogen
Rosiglitazone
Dydrogesterone
Saquinavir
Ergoloid mesylate
Selegiline
Erythromycin
Simvastatin
Estramustine
Sulfasalazine
Ethosuximide
Telithromycin
Etoposide
Terbinafine
Exemestane
Terfenadine
Felbamate
Testosterone, transdermal patch
Felodipine
Tetracycline
Fluconazole
Theophylline
Flunitrazepam
Thiamazole
Fluvastatin
Tibolone
Glibenclamide
Ticlopidine
Halothane
Tinidazole
Hyoscyamine
Thiotepa
Imipramine
Topiramate
Irinotecan
Topotecan
Isoniazid
Toremifene
Isradipine
Tramadol
Itraconazole
Trimegestone + estrogen
Lamivudine +zidovudine
Verapamil
Lansoprazole
Voriconazole
Lercanidipine
Zidovudine/AZT
Levonorgestrel



Possibly Porphyrinogenic 
Aceclofenac
Gramicidin
Phenylpropanolamine + cinnarizine
Acitretin
Guaifenesin
Pizotifen
Acrivastine
Hydrocortisone
Polidocanol
Alfuzosin
Hydroxycarbamide
Polyestradiol phosphate
Anastrozole
Hydroxychloroquine
Potassium canrenoate
Auranofin
Ibutilide
Pravastatin
Azelastine
Imatinib
Prednisolone
Benzatropine
Indomethacin
Prilocaine
Benzydamine
Ketobemidone + DDBA
Proguanil
Betaxolol
Ketorolac
Propafenone
Bicalutamide
Lamotrigine
Pseudoephedrine + dexbrompheniramine
Biperiden
Letrozole
Quillaia extract
Bupropion
Levodopa + benserazide
Quinagolide
Carvedilol
Levonorgestrel intrauterine
Quinine
Chlorambucil
Levosimendan
Quinupristin + dalfopristin
Chlorcyclizine + guaifenesin
Linezolid
ReBoxetine
Chloroquine
Lofepramine
Repaglinide
Chlorprothixene
Lomustine
Rizatriptan
Chlorzoxazone
Malathion
Rofecoxib
Chorionic gonadotrophin
Maprotiline
Ropinirole
Ciclosporin
Mebendazole
Ropivacaine
Cisapride
Mefloquine
Roxithromycin
Citalopram
Melperone
Sertraline
Clomethiazole
Melphalan
Sevoflurane
Clomiphene
Mepenzolate
Sibutramine
Clomipramine
Mepivacaine
Sildenafil
Clopidogrel
Mercaptopurine
Sirolimus
Clotrimazole
Methadone
Sodium aurothiomalate
Cortisone
Methylprednisolone
Sodium oleate + chlorocymol
Cyclandelate
Metixene
Stavudine
Metolazone
Cyclophosphamide
Sulindac
Cyproheptadine
Metronidazole
Sumatriptan
Dacarbazine
Mexiletine
Tacrolimus
Daunorubicin
Mianserin
Tadalafil
Desogestrel
Midazolam
Tegafur + uracil
Dichlorobenzyl alcohol
Minoxidil
Telmisartan
Dithranol
Mirtazapine
Thioridazine
Docetaxel
Mitomycin
Thioguanine
Donepezil
Mitoxantrone
Tolphenamic acid
Doxycycline
Moclobemide
Tolterodine
Ebastine
Montelukast
Torsemide
Econazole
Morphine + scopolamine
Triamcinolone
Efavirenz
Multivitamins
Trihexyphenidyl
Escitalopram
Mupirocin
Trimipramine
Esomeprazole
Nabumetone
Valerian
Estradiol/tablets
Nafarelin
Venlafaxine
Estriol/tablets
Naltrexone
Vinblastine
Estrio/vainal crème, tablet
Nateglinide
Vincristine
Ifosfamide
Nilutamide
Vindesine
Estrogen, conjug.
Noscapine
Vinorelbine
Finasteride
Omeprazole
Xylometazoline
Flecainide
Oxybutynin
Zaleplon
Flucloxacillin
Oxycodone
Ziprasidone
Fluoxetine
Pantoprazole
Zolmitriptan
Flupentixol
Papaverine
Zolpidem
Flutamide
Parecoxib
Zuclopenthixol
Fluvoxamine
Pentifylline

Follitropin alfa and beta
Pentoxyverine

Galantamine


Glimepiride


Glipizide


Gonadorelin


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