55 - Drugs causing Megaloblastic anemia

1. Phenytoin (anticonvulsant)

2. Primidone (anticonvulsant)

3. Phenobarbitone (anticonvulsant)

4. Sulfasalazine

5. Nitrous oxide
6. Folate antagonists (inhibitors of Dihydrofolate reductase) like Methotrexate, Pentamidine,     Pyrimethamine, Triamterene, Trimethoprim and Cotrimoxazole.
7. Drugs that inhibit DNA synthesis may cause Megaloblastic anemia
    example : 6a. Purine antagonists = 6-Mercaptopurine, Azathioprine.
                   6b. Pyramidine antagonists = 5 FU, Cytosine arabinoside .

                   6c. Others = Hydroxyurea, acyclovir and zidovudine (AZT, Azidothymidine).
8. Nitrofurantoin (less well documented)
9. Tetracycline (less well documented)
10. Anti-Tuberculosis drugs (less well documented)

54 - Monoclonal antibodies approved for Hematological and Solid tumors

ANTIGEN AND TUMOR CELL TARGETS	ANTIGEN FUNCTION	NAKED ANTIBODIES
Antigen: CD20	Proliferation/differentiation	Rituximab (chimeric)
Tumor type: B-cell lymphoma and CLL
Antigen: CD52	Unknown	Alemtuzumab (humanized)
Tumor type: B-cell CLL and T-cell lymphoma
Antigen: CD25 alpha subunit	Activation antigen	Daclizumab (humanized)
Tumor type: T-cell mycosis fungoides
Antigen: CD33	Unknown	Gemtuzumab (humanized)
Tumor type: acute myeloid leukemia
Antigen: HER2/neu (ErbB-2)	Tyrosine kinase	Trastuzumab (humanized)
Tumor type: breast cancer
Antigen: EGFR (ErbB-1)	Tyrosine kinase	Cetuximab (chimeric)
Tumor type: colorectal; NSCLC; pancreatic, breast
Antigen: VEGF	Angiogenesis	Bevacizumab (humanized)
Tumor type: colorectal cancer