2 - anti-malarials mcqs

1- which of these drugs is the latest addition to the list fo antimalarials ?
a-mepacrine
b-primaquine
c-ARTEMISININ
d-pyrimethamine

2-Question 2
Which of these phases of malarial parasite is the target for prophylactic treatment?
PRE-ERYTHROCYTIC PHASE IN LIVER
Erythrocytic phase
Exo-erythrocytic phase
Any of the above

Question 3
Which of these drugs is not used for prophylaxis of malaria?
QUININE
Chloroquine
Primaquine
Chloroguanide

Question 4
Chloroquine as a prophylactic drug is used in the following dose:
100mg (base) weekly
200mg (base) weekly
300MG BASE WEEKLY--
400mg (base) weekly


Question 5
Which of the following enzyme deficiency should be ruled out before starting Primaquine therapy?
GLUCOSE 6 PHOSPHATE DEHYDROGENASE (G6PD)
lysosomal enzymes
Pancreatic lipase
Pancreatic amylase

6-Drugs attacking which phase of malarial parasite can provide radical cure?
Pre-erythrocytic phase (In liver)
Erythrocytic phase
EXO- ERYTHROCYTIC PHASE
None of the abovE

7-Question 7
Which of these drugs can provide radical cure for falciparum malaria but not for relapsing malaria?
Chloroquine
Mepacrine
ARTEMISININ
Any of the above

Question 8
Primaquine as a radical cure for malaria is used in the following dosage:
15 mg daily for one week
15 MG DAILY FOR TWO WEEKS
15 mg daily for three weeks
15 mg daily for four weeks

Which of these statements is not true with regard to chloroquine?
Plasma half-life varies from 3-10 days
Selective accumulation in retina is responsible for ocular toxicity with prolonged use
CANNOT BE USED IN PREGNANCY
May precipitate an attack of psoriasis

Question 10
Artemisinin group of drugs attack which phase of malarial parasite life cycle in humans?
Pre-erythrocytic phase (In liver)
ERTHROCYTIC PHASE
Exo-erythrocytic phase
All of the above

Question 11
Which of these drugs is not preferred as a therapy in cerebral malaria patients?
Quinine
CHLOROQUINE
Artemether
Artesunate

Question 12
Loading dose of quinine in cerebral malaria is
10mg/kg by i.v. infusion
20MG/KG BY I.V. INFUSION
30mg/kg by i.v. infusion
40mg/kg by i.v. infusion

Question 13
Which of these statements is not true with regard to Artemisinin?
Artemisinins act very rapidly, reducing parasitaemia by a factor of 104 with each cycle
Artemisinin drugs are short acting
When used as monotherapy the dose is 2.4 mg/kg on day one followed by 1.2 mg/kg for six days
CAN ONLY BE GIVEN IN INJECTABLE FORM

Question 14
According to WHO recommendations, if artesunate is given for less than seven days, treatment should be followed by a therapeutic dose of:
MEFLOQUINE
Pyrimethamine
Chloroquine
Quinine

Question 15
Artesunate can be given in combination with:
Mefloquine
Chloroquine
Sulfadoxine-Pyrimethamine
ALL THE ABOVE .