23 - prodrugs and active forms

MCQ: all of the following are prodrugs except ?

a. lisinopril

b. enalapril

c. levodopa

d. sulindac

answer: a . lisinopril .

PRODRUGS AND ACTIVE FORMS

1. LEVODOPA ------------------- dopamine

2. ENALAPRIL ------------------- enalaprilat

3. SULINDAC --------------------- sulfide metabolite

4. BECAMPICILLIN –---------- ampicillin

5. SULFASALAZINE –---------- 5 – aminosalicyclic acid

6. PREDNISONE ----------------- prednisolone

7. ZIDOVUDINE ----------------- zidovudine triphosphate

8. CYCLOPHOSPHAMIDE --- aldophosphamide

22 - theophylline - drug interactions

THEOPHYLLINE -- DRUG INTERACTIONS

1. drugs which inhibit theophylline metabolism and increase its plasma level :

1. allopurinol
2. cimetidine
3. ciprofloxacin
4. erythromycin
5. OCP

2. drugs which induce theophylline metabolism and decrease its plasma level are :

1. phenytoin
2. phenobarbitone
3. charcoal broiled meat meal
4. rifampicin
5. smoking

3. theophylline enhances the effect of the following drugs:

1. hypoglycemics
2. furosemide
3. digitalis
4. oral anticoagulants
5. sympathomimetics

4. theophylline decreases the effect of :

1. lithium
2. phenytoin